This can be useful in getting the guix dirs persistent in qubes
http://qubesosfasa4zl44o4tws22di6kepyzfeqv3tg4e3ztknltfxqrymdad.onion/doc/bind-dirs/
Long story short, since it seems like guix package manager writes to /gnu/store/ directory, in normal qubes, the changes in there don’t survive a reboot. But, turning that dir in a bind-dir seems to make it survive a reboot, and enable using guix inside a qube.
Also related topics: