For anyone who jumps into the Framework Laptop 11th gen at this point (such as the HCL report is for this post), at this point the laptop works very well and new kernels have resolved all the major issues. I have posted a guide for Framework laptop users, for all generations, here on github Setting up and tweaking Qubes OS 4.1 and 4.2 on Framework Laptop · GitHub.
I will also be building one out in the forums: Framework Laptop Set up and tweaking Guide [Orca Project 2]