Did you ever solve this? I’m also getting this:
Jan 13 00:56:30 sys-audio pipewire[1724]: mod.qubes-audio: org.qubes-os.audio-domain-xid not specified, and no /qubes-audio-domain-xid entry in QubesDB
Jan 13 00:56:30 sys-audio pipewire[1724]: pw.conf: 0x58c6705941e0: could not load mandatory module "libpipewire-module-qubes": No such file or directory
Jan 13 00:56:30 sys-audio pipewire[1724]: default: failed to create context: No such file or directory
Jan 13 00:56:30 sys-audio systemd[661]: pipewire.service: Main process exited, code=exited, status=254/n/a