Note, I should edit the guide to go back to patching the source code: Sys-audio drops qubes on restart - #2 by neowutran
Should also open a github issue ticket to better understand this issue, I expect it to be a cache issue.
For the issue mentionned by @ymy and here: [sys-audio] Audio cutting in and out making audio unusable
If you can, try to check the cpu consumption of sys-audio and dom0, run “top” and check what are some of the most CPU hungry process.
Don’t have much time currently to do that properly, I have the new FFXIV extension to farm 