@grey (or somebody else affected by this issue) can you test kernel with the patch included? I uploaded it into the qubes-dom0-unstable repository as kernel-latest-qubes-vm version 6.18.4-1.qubes.2.fc41. You can install it using qubes-dom0-update --enablerepo=qubes-dom0-unstable --action=update kernel-latest-qubes-vm (and then switch sys-usb to that kernel version).