It is possible. I’m currently using it. It would be very useful if you install QWT for copy/paste between qubes.
You cannot passthrough USB device other than storage. Thus, you cannot passthrough any usb devices(webcam, microphone, printer, smartphone, etc…) on Windows even if you successfully installed QWT(since usb passthrough is not supported).
You can adjust screen resolution on Windows 10. But not all settings possible.