I last followed Qubes years ago so forgive me if my knowledge is out of date.
My Qubes machine which has mostly been catching dust is the intel ME neutered + skulls T430, but I am interested in upgrading it to a newer machine now.
Last I was aware, the main risk of using that line of laptops was that a compromised VM could read the contents of another VM.
The Qubes team at the time advised not running sensitive VMs at the same time as non sensitive VMs to mitigate the risks.
I was considering the T480, but it also doesn’t get microcode updates.
I am considering dishing out cash for a certified laptop, but they’re mighty expensive.