Recently I began configuring Qubes 4.1 on an Alienware x17 but one of my final issues is PCI attachment or passthrough.
(compatibility side note)------------------------------------------
I have managed to get almost everything operational. I had to solve USB keyboard issues, and update wifi for the killer wifi card. I also had to change some configurations in order to have backlight controls and had to adjust bios for graphics. I still need to solve PCI attaching and Bluetooth.