You can make any Qube autostart if that’s what you are asking about. However, designing a coherent workflow with browser extensions without compromising the security is not that easy. Probably qubes-url-redirector and this howto [Guide] Automatically install extensions and configure new (dispvm) Firefox profiles with arkenfox user.js and policies would be a good point to start. I’d suggest keeping the Joplin browser plugin in one Qube and opening links there when necessary.
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