Probably not Qube but? (MSI board boots straight to bios for hard drive but not usb stick?)

[apparatus]

You can try to add EFI boot entry from Qubes OS installer:

BIOS Update That Will Break Boot

If you use uefi : get a qubes os media installation. boot to qubes os rescue mode. skip to shell. [shell] : efibootmgr -v -c -u -L "Qubes OS" -l /EFI/qubes/grubx64.efi -d /dev/nvme0n1 -p 1 reboot change -d <which drive?> and -p <which efi partition?>. if you want you can make sure first by issuing efibootmgr -v in dom0

If it won’t work then you can also try to use EFI fallback and add it like this:

UEFI boot: no Qubes OS option

This issue explains more about UEFI boot entries missing. There are also instructions there for fixing UEFI Mount the bootloader partition Copy the contents of /mnt/EFI/qubes/ to /mnt/EFI/BOOT/ Rename grubx64.efi to bootx64.efi Rename grub.cfg to bootx64.cfg efibootmgr -v -c -u -L Qubes2 -l /EFI/BOOT/bootx64.efi -d /dev/sda -p 1

If it works then you can add postinst kernel hook so it’ll update these files automatically on dom0 updates:

Raw disk backup of Qubes EFI is unbootable