OK, so no BTRFS, it will be EXT4 then !
Since I don’t need Snapshots, because external back-ups (using TimeShift ? LuckyBackUp ?)
As for the mountpoints, I see in this post a different name:
You suggested ./appvms/
They suggest qubes_dom0-vm-pool
I just noticed that you are using VisualStudio, but I’m using Catia and Rhinoceros, and while I did find some posts about ViStu on Xen, I didn’t find much about Catia or Rhino on Xen … nothing positive at least
Here is what the current idea looks like, in a more visual way