Started using Qubes OS 4.1 on this machine early 2022 and it seems to me everything works fine. Did the in-place-upgrade 4.1 > 4.2 today. Only two issues after the upgrade; had to make dom0 accept USB mouse again and had to disable persistently the security-testing repo in fedora-template and enable current-testing to replace it.
Used Qubes on this Notebook more as a year. Video, audio, network, graphics all okay.
Two HCL reports: before and after the in-place-upgrade.