P.S.
For enterprise Microsoft 365 deployments, note that the service gathers substantial OS telemetry, enforces compliance policies to restrict unauthorized devices, and enables SOC teams to monitor and identify suspicious activity originating from your environment.
2007+2010 are supposed to work with wine without any issues.
2013+2016+2019 might work with winetricks and some guides.
2021+365 are probably not working.
I think your best bet is a VM with Windows. Alternatively, M$ Office Online or OnlyOffice, the latter if format compatibility is the only thing that’s necessary.
My understanding is that ReactOS will now run MS Office up to version 2010, but until Qubes-windows-tools runs on ReactOS, it’s probably better to just use Codeweavers.com CrossOver® Linux ($74). Yes, it’s better to use Libre software when possible, but you’ll be paying for Microsoft Office anyway. With Codeweavers, you are at least using the Wine infrastructure and adding to the ongoing Libre infrastructure. The Wine project does benefit from what Codeweavers is doing.
Edit: Just checked Codeweavers compatibility with Office, and it appears that Office 2024 still does not install, so an older version of Office will still be required.
LibreOffice does most of the tasks for MS Office, including openning .docx files, but if true MS Office needs to be used, I’d go with separate Win VM. I’m actually using it for mandatory accounting software and also for adobe products as well. Playing with wine and other workaround are waste of time. Wine is good for simple win programs, anything complicated can’t be run with it.
If you are looking for an alternative for Adobe software, someone made very similar programs with Claude. I have looked at the alternative to the Acrobat reader and also MS Word. And they are nearly identical but without bloat, spyware, account nonsense and they are free and open source:
I haven’t used the premium products of Adobe but I heard that the open source alternatives are very good.