Currently using a zen 4 cpu
( zen 4 7950X + asus rog STRIX X670E-F + 128gb ram + RTX 4080 )
The road have been quite long ( https://forum.qubes-os.org/t/ryzen-7000-serie/ ), but all the required upgrade and patch are in qubes development tree (xen + libvirt upgrade + xen patch). Should work out of the box with Qubes R4.2.
I still have a lot of tests to do. I will update my “ryzen-7000-serie” posts until I can confirm that everything work.