I am a new user, moving from Windows 7.
My machine does not provide VT-d. That is obvious right from installation, the installer identifies the lack of this attribute, and allows to continue installation (coherent with UserFaq).
After installation, it is possible to successfully boot into the system, but only the 1st boot. All next boot attempts seem to “hang” (as we are somewhat used to in Windows, sometimes the system just does nothing, and there is no response to any input) at the login screen. But it does not “hang”, although any input seems not to have any effect. Upon rebooting, and editing the grub script with qubes.skip_autostart, both keyboard and mouse work as expected, everywhere. Thus, it is a problem with sys-usb and hardware passthrough.
The instructions for Installation troubleshooting — Qubes OS Documentation were followed. The advanced properties of the vms were altered, grub was edited, followed by sudo grub2-mkconfig -o /boot/efi/EFI/qubes/grub.cfg, and next, the undocumented sudo dracut -f for getting the LUKS nicer password screen. The problem persists. After the LUKS password is entered, both keyboard and mouse have no effect on the login screen.
The only method to login is rebooting, editing grub, and add qubes.skip_autostart.
Thus, the information provided in the documentation is insufficient (there are missing steps), or is wrong (this behaviour is expected, the documentation drifted from the design/implementation of Qubes OS itself).