I recently did a clean install of 4.1-rc2. On 4.0 I was using the Display app to manually select 1920x1080. This worked OK except that it always lost the setting after a suspend/resume.
For 4.1, I am leaving the display set at 3840x2160, and have found a series of kluges which more or less seem mostly better (not having to use Display to manually set 1920x1080 being one advantage).
One thing I have yet to track down is how to make certain dom0 apps scale correctly.
None of the Qubes-Tools obey any of the scaling directives I have set. In the Appearance/Settings I have ‘window scaling’ set to 2x. That fixed a lot of things, but I still needed some kluges for the AppVMs.
This works well in VMs derived from certain templates:
gsettings set org.gnome.settings-daemon.plugins.xsettings overrides "[{'Gdk/WindowScalingFactor', <2>}]"
Others require some ~/.Xresource settings for xterm:
xterm*background: black
xterm*foreground: yellow
xterm*faceName: monospace:pixelsize=32