I have been using (testing) Fedora 42 as my default Templates for over a week (including minimal Fedora 42 templates for ServiceVMs). Details here:
In addition to the explanation in the above post, Fedora 42 has some other cool features. Bees is packaged for it (For BTRFS de-duplication if you need it). Xfce 4.20 has experimental Wayland support features. A pretty new Anaconda installer (which itself is wayland based), DNF/RPM CoW, etc.
Having said that, we do not have enough time. It is more feasible to backport highly essential packages to Fedora 41 for dom0 rather than supporting all of the above for Qubes OS 4.3 (as there are a tone of them). And Fedora 42 templates could be individually provided. I believe we will have to wait for Qubes OS 4.4 (or maybe 4.3.1) for Fedora 42 support.