DNS-Over-HTTP in Qubes?

I recently set up Atlas OS (based on Windows 11) in my desktop.
With this being my first foray into switching from Win 10 to 11, one of the neat things I discovered was turning on DNS-Over-HTTP system-wide in the network settings.

So that got me thinking, can I enable system-wide DNS-Over-HTTP in Qubes (and any Linux distro for that matter)?

You can read this topic to get the idea on how to do this:

You can also use a Pi-hole for this:

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+1, I’m also using dnscrypt-proxy for this in a network VM. works like a charm.