I haven’t worked with it before, but considering it is described as a “XenStore client” it sounds like it is using the same underlying infrastructure.
Are you able to describe what your higher-level goal is? AFAIK XenStore provides pretty good isolation between different VMs (assuming that grants are managed properly). If you’re trying to avoid any writes to the disk, then QubesOS isn’t a good solution for you in its current state. The thread about “truly” disposable VMs might work, but I don’t know how well it’s been vetted (I haven’t read through the thread so maybe it’s been vetted pretty well, I just don’t want to imply an endorsement when I lack information).