I’ve been using it for the past year with Qubes. Now even installed the official 4.1 version and so far I haven’t encountered the touchpad issue (although I usually use an external mouse). Even the problem with having to unplug HDMI on every startup (to avoid the computer hanging) seems to be fixed.
The LED thing has never turned on and I haven’t bothered but as @unique commented there’s the asus-linux / asusctl · GitLab which might make it usable (along with other ROG-specific features).
Overall I would consider this a great Qubes laptop.