Let me link to unman’s post :Can AI tools help answer Qubes OS support questions? - #6 by unman
I think R4.2 should already include newer cryptsetup that can auto scan for disk’s LBA sector size and choose the right luks sector size. But I think currently btrfs qubes setup on 4kn drive isn’t really taking advantage of 4kn, unlike lvm-thin. And you need to “do esoteric things” building 4kn templates to make lvm-thin setup on 4kn work: VMs don't boot on 4Kn drive · Issue #7828 · QubesOS/qubes-issues · GitHub