What about a more casual qubes?

Your question is like my comments.

Very cumbersome of Qubes os is passwordless-root.
This is not able to KVM, if user uses lightweight Qubes os by KVM, user must enter password all VMs.
So usability of Qubes os is very good, but user can not choice any init system and distributions on Qubes os, user have not freedom of init system choice.

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