I just did a dom0 update of about a dozen packages from qubes*-testing repos, which included some qubes-core* 4.1.10-1 packages.
This resulted in a system that could sometimes boot to the desktop, but everything else was jammed: qvm-start would just freeze and so did lvm-related commands. Also, all the qubes-specific systray icons appeared as black squares and were unresponsive.
I was later able to revert to a prior snapshot of ‘qubes_dom0/root’ lv to get the system working again.
I did save the dnf history and syslog from that session but I didn’t notice any qubes-specific failures in it.