Sys-usb - where to add irqpoll when getting "irq 44: nobody cared (try booting with the "irqpoll" option)"

sys-usb works with one device (my yubikey). After booting, i get a shell in sys-usb, do lsusb and all is good. Then i plug in a second USB device (a usb mouse), and then I found this chunk in dmesg (pasted below). It’s not obvious if its recommending adding irqpoll to the xen grub /etc/defaults/grub or if its recommending adding irqpoll to the usb-sys boot procedure.

[  680.028708] irq 44: nobody cared (try booting with the "irqpoll" option)
[  680.028800] CPU: 0 PID: 0 Comm: swapper/0 Tainted: G           O      5.4.98-1.fc25.qubes.x86_64 #1
[  680.028872] Hardware name: Xen HVM domU, BIOS 4.8.5-30.fc25 02/18/2021
[  680.028913] Call Trace:
[  680.028933]  <IRQ>
[  680.028954]  dump_stack+0x66/0x81
[  680.028981]  __report_bad_irq+0x30/0xc0
[  680.029007]  note_interrupt+0x232/0x270
[  680.029032]  handle_irq_event_percpu+0x51/0x70
[  680.029062]  handle_irq_event+0x36/0x60
[  680.029086]  handle_fasteoi_irq+0x83/0x130
[  680.029111]  generic_handle_irq+0x24/0x30
[  680.029136]  __evtchn_fifo_handle_events+0x14c/0x1b0
[  680.029169]  __xen_evtchn_do_upcall+0x70/0xd0
[  680.029199]  xen_evtchn_do_upcall+0x27/0x40
[  680.029225]  xen_hvm_callback_vector+0xf/0x20
[  680.029254]  </IRQ>
[  680.029271] RIP: 0010:native_safe_halt+0xe/0x10
[  680.029302] Code: ff eb bc 90 90 90 90 90 90 90 90 90 e9 07 00 00 00 0f 00 2d 86 8d 5e 00 f4 c3 66 90 e9 07 00 00 00 0f 00 2d 76 8d 5e 00 fb f4 <c3> 90 0f 1f 44 00 00 41 55 41 54 55 53 e8 30 f1 73 ff 65 8b 2d b9
[  680.029400] RSP: 0018:ffffffff8d603e78 EFLAGS: 00000246 ORIG_RAX: ffffffffffffff0c
[  680.029443] RAX: ffffffff8ca1fc90 RBX: 0000000000000000 RCX: 7fffff61bbbe9658
[  680.029484] RDX: 0000000000000000 RSI: 0000000000000000 RDI: ffff911b10c1c500
[  680.029526] RBP: 0000000000000000 R08: 000000002c5b3698 R09: 000000000000031a
[  680.029568] R10: ffff9daac02c3d88 R11: ffffffff8d65a000 R12: ffffffff8d614780
[  680.029609] R13: ffffffff8d614780 R14: 0000000000000000 R15: 0000000000000000
[  680.029652]  ? __cpuidle_text_start+0x8/0x8
[  680.029678]  default_idle+0x1c/0x140
[  680.029703]  do_idle+0x1bd/0x270
[  680.029733]  cpu_startup_entry+0x19/0x20
[  680.029761]  start_kernel+0x7d7/0x819
[  680.029787]  secondary_startup_64+0xb6/0xc0
[  680.029811] handlers:
[  680.029830] [<00000000ff979979>] usb_hcd_irq
[  680.029875] Disabling IRQ #44

i successfully got both a yubikey and a mouse working by passing only 2 of the usb pci devices to sys-usb, instead of every usb device on the system.

i think one or more of the usb pci devices was causing the issue

(added some markdown formatting to your post to increase legibility)