Suddenly problem with HAP/SLAT and Remapping

I changed some hardware on a system with a Ryzen 5700G and a B550 Board ( NVME, HBA and removed some RAM).
I also changed some BIOS settings.

Everything worked perfectly fine until I noticed that after a while the qubes-hcl-report reports that that HAP/SLAT and Remapping are not supported anymore???

HVM:		Active
I/O MMU:	Active
HAP/SLAT:	Unknown ("xl dmesg" incomplete)
TPM:		Device present (TPM 2.0)
Remapping:	no
Certified:	no

To be clear this probably was not the case 1 month ago and the first 10m-20m after boot and normally using the system it is reported as supported…

I am not too stoked about disassembling the whole thing and test boot with every little component / bios setting changed, that will take forever.
Could it be that the new PCI/HBA card could be the culprit?

Does anybody have any idea what’s going on here?
Why does it only occur after a while?

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This is driving me nuts. I cannot find anything obvious in system logs.

xl demesg spits out io_page_faults for some usb controllers. But I don’t think that’s it

Can I disable XHCI Hand-off for qubes?