No issue on my side.
Qubes OS 4.2, archlinux with an 4080 GPU (~yukikoo/gpu_template - Auto install a templateVM suitable for GPU passthrough, using the archlinux community template - sourcehut git)
[user@jeux ~]$ vglrun glxinfo -B
name of display: :0
display: :0 screen: 0
direct rendering: Yes
Memory info (GL_NVX_gpu_memory_info):
Dedicated video memory: 16376 MB
Total available memory: 16376 MB
Currently available dedicated video memory: 15703 MB
OpenGL vendor string: NVIDIA Corporation
OpenGL renderer string: NVIDIA GeForce RTX 4080/PCIe/SSE2
OpenGL core profile version string: 4.6.0 NVIDIA 570.153.02
OpenGL core profile shading language version string: 4.60 NVIDIA
OpenGL core profile context flags: (none)
OpenGL core profile profile mask: core profile
OpenGL version string: 4.6.0 NVIDIA 570.153.02
OpenGL shading language version string: 4.60 NVIDIA
OpenGL context flags: (none)
OpenGL profile mask: compatibility profile
Didn’t tried R4.3