While I cannot say what’s the situation with the Ryzen AI processor’s NPUs, I would not get an AMD to use the NPU in Qubes (passthrough seems to not be supported due to hardware constraints, and the virtualization solution available is kvm-based so it is not clear it will be applicable to Xen) until I see someone getting it to work. That will not change with 4.3, I am quite sure.
I cannot say anything about Intel though, as their hardware (and drivers) are different. But no Qubes version will be able to use the NPU as a GPU, if that’s what you would like to happen.