I'm not sure what thread you're referring to (re SEV).
Actually it was a discussion on GitHub qubes-issues:
A few of us are
running Qubes 4.1 alpha on new Thinkpad Ryzen 7 PRO 4750U systems
because the older version of Xen used in Qubes 4.0 is incompatible.
The newer Xen in R4.1 alpha still has a bug that affects CPU scheduling,
so there is a trick to configuring it for a smooth running system.
Qubes reports that safety features (IOMMU etc) are working. What does
not currently work is S3 sleep.
Stability is already quite good if you avoid badly-behaved wifi drivers
(unfortunately the Thinkpad's Intel AX200 is in this category, so I use
a USB wifi device instead).
I'd say its not too much of a gamble if you're willing to run a new
alpha or beta of Qubes. But keep in mind your 4750G motherboard may have
significant differences vs Thinkpad laptops; IMO you need to go with a
high-quality brand, preferably a pre-built business system from the
traditional top-3 (Lenovo, Dell, HP).
That's encouraging, thank you very much for all the information. It indeed doesn't look like too much of a gamble then, besides I really don't mind waiting a bit. The current Qubes machine is just fine and will be for some time, the new machine is intended to become its successor. Thanks Chris.