I installed Qubes OS 4.2.4 two days ago on a Lenovo P16 Gen2 and it runs flawless. It is curious that I have not noticed any difference in battery life respect to RedHat, my previous OS, and Windows 10, the OS installed on my second hard disk.
Hardware:
RAM: 128 GB ECC
PROCESSOR: Intel 9 13950HX vPRO
SMT: Disable