I will make a more thorough post about this and some may not be 4.1 specific but for Purism Librem 14:
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constant charging/discharging alerts/notifications when computer into power (and yes i have followed all the instructions on forums for fixing this on 4.0 - the only workaround is to completely disable power notifications in dom0)
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wifi radio is missing when resume from standby
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3.5mm does not work
other
for some reason occasionally on startup sys-net and sys-firewall does not run and requires manual start …this i noticed started with rc4.