Follow this guide:
In mybrowser.desktop
set Exec to:
Exec=/usr/bin/qvm-open-in-vm -- @default %u
And the policy in dom0 to:
qubes.OpenURL * @anyvm @default allow target=Browser
But you you can specify the qube name as well without using @default:
Exec=/usr/bin/qvm-open-in-vm -- Browser %u
And:
qubes.OpenURL * @anyvm Browser allow