The title of this thread struck a chord with me because I remember writing an email to Ms Joanna back in early 2018 to thank Qubes OS for helping to shape my online working system into a more advanced level of operation. The whole thought process for navigating the World-Wide Web becomes clearer with this compartmentalisation of different types of sites. The categorisation of the system enables the categorisation in the mind of the user, so I have found.
I’ll try not to get too locquacious because I always tend to do so, but briefly list the organisation of the sixteen(16) VMs I’ve been using for the past few years, almost now.
First of all there are three(3) offline VMs. BASE, PLAY, and SAFE.
BASE is my main working VM for offline housekeeping, writing, graphic design, photos, file management; the basic stuff
PLAY is for the games, because I am not much good at games so best play against myself or a computer than other living opponents who usually beat me at anything. That is why I don’t play games online.
SAFE is the least used and most secure, which has confidential data such as passwords and things like that, if I ever forget something. SAFE probably only gets used once a year or less, but it has the secret stuff locked away, offline. If anyone ever got in there, all the files are encrypted and then compressed, so it’s quite protected, and that’s why I hardly ever bother forgetting anything anymore. 
That covers the three(3) offline VMs. Now for the online. It seemed like a good idea at the time in 2018 to follow the groupings of top-level domains. COM, EDU, GOV, MIL, NET, ORG.
These all have a Web- prefix, so Web-Com is the VM for online shopping, Web-Edu (actually I used Web-Dev for development but it should have been Edu) is for the Qubes website and other IT related sites, Web-Gov is for stuff like Dept. of Transport or other government agencies, Web-Mil is dedicated to Facebook, and ‘mil’ could stand for ‘military’ or ‘grinding mill’, then Web-Org contains websites which are generally social and friendly, and opens with the weather website for wherever I might happen to be that day.
There are also four(4) additional online VMs: Web-Bank, Web-Mail, Web-News, and Web-Wild.
Web-Bank is firewalled to only access my bank’s domain, and that’s the best security I can come up with.
Same for Web-Mail, which is firewalled to my email provider’s URL.
Web-News is now mainly used to grab the latest news from Youtube because they all post the stories there and it is easier to scan over the Youtube list and get the news from all the different sources.
Lastly Web-Wild is the joker in the deck. For miscellaneous outliers, and includes Google Translate for some reason, probably because a translator might be useful across other VMs but should not be associated with any of them. I don’t want Google to know which weather website I am on tomorrow, nor facebook to know what I am shopping for this week.
Qubes OS has really been both very helpful as well as enlightening because I am not getting tracked by those charlatans anymore, and I can understand how the different online operations operate in the context of the original top-level domains. The magnitude of this change is something quite significant, a bit like moving from the VIC-20 to the Amiga 500 all those years ago.
Yeah, thinking with Qubes is to thinking with Linux like living in mud huts is to living in hi-rise condominiums, and view is fantastic! , .
PS: I forgot to mention the three(3) Whonix VMs, after proof-reading and counting through the paragraphs. Well these are best left unspoken, but those three make up The Sixteen VMs.