I am facing one more new usability problem that may be related. This past week for the first time some Qubes with 400 MB Initial Memory and 4000 MB Max Memory are stuck at 400 MB and are unusable. These are two screenshots. Browse Qube is stuck at 400 MB RAM, and Disposable Whonix disp9125 is also stuck at 400 MB RAM.
This problem was only fixed after rebooting Qubes OS. My computer has 32GB RAM.