Thanks for the update @helge. Must be like you said - something in 4.1
Mine using the github guide on 4.0.3 is working well.
I have no Trezor to test your thought, unfortunately. I do have a Ledger S, and I came across the ‘How-to: Ledger Hardware Wallet in Qubes’, but I’ve not had the chance to mess with it so far. Plus it looks to be a completely different trip to the Trezor method you point to.