Looking to switch to a ThinkPad from a Librem14 Suggestions welcome

Sorry if this question is redundant but I just want double check.
My laptop only has I believe one usb controller. Is it possible to follow your setup and preserve my default sys-usb to function normally (i.e. handle keyboard/mouse/storage/display in offline standard mode) and simultaneously following your guide to use USB-ethernet? Or does this require a computer with more than one USB controller to work as you describe?

I am also curious if you have a computer with multiple USB controller why don’t you just create multiple sys-usb and just make one of them online and the rest offline? I am confused as to what the advantage is doing this way you are doing when you have multiple usb controller and can compartmentalize.