Definitely!
I got started using VMWare around 2000 and used that to “tame” the pile of dogshit that Win98 was, had data on a separate drive and just refreshed the whole install once or even twice a day while working with Pagemaker & Photoshop 
Since then I’ve been testing out most variants of VM setups, and had several in production, but so far Qubes is the only way of doing this (for my needs) that feels just right!
I would guess its a mix of being able to see and use any number of applications and VMs in one screen that makes it useful enough to dive deep into & solve any hickups whereas with Virtualbox I’d just be onto the next distro if something doesn’t work and then implement what works there on a VPS or such.
For some reason my Windows Qubes die after a while so I have to reinstall, maybe that was happening when my previous laptop ran out of battery power or such. Will get around to taming Windows fully soon.
As a sidenote to that I’ve depended on Windows maybe at max a year in total since I got into computing in 84 or so
With Qubes I can use that horrible contraption for occasional things & then just wipe the slate, now that is perfection!