Is it possible to add a second SATA disk?

at the moment there is only one SATA SSD connected on which Qubes OS is installed.

I want to shut down the system and connect an additional SATA HDD.

Questions:
1.
Will the system then boot without problems?
Or do I have to change any boot parameters?
2.
If it does not boot, will anything be changed in the MBR, GRUB or other boot settings?
So that the system won’t boot at all, even if I remove the second SATA disk?

Adding a second drive should not prevent Qubes OS from booting.

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