Is it possible for QubesOS to not feel choppy, like you're not using a virtual machine?

Unsolvable. This video will not be played smoothly on any CPU in Qubes OS:

The problem is in Xen/Qubes OS rendering approach. It does not depend on CPU that much.

But in R4.3 (fedora-40+ templates) there is a major bug - video playback is choppy in Firefox.
To wordaround this bug you can install Firefox from flatpak, the video playback would be much-much smoother.