Not a security professional here, but as far as I know the whole point of an audio qube is to:
- Protect audio from everything else (talking about your mic of course), therefore there is not much difference between smart audio and analog stuff, especially when your audio qube is not connected to the internet.
- Make it convenient to control your audio setup through somewhat centralized combination of dom0’s pulseaudio and audio qube’s loopback modules.
It is not as hard as it seems to set up an audio qube, and there are community guides for that:
USB audio device ← this is not really about USB, it will work with other devices
External audio
P.S.
If you want to “raw dog” it, you will need to connect your audio device directly to the source (and/or target) of the sound, not the dom0.