My first (stupid) issue was a buggy 4GB USB stick, I switched to a newer and bigger one for the QubesOS 4.0 ISO.
My second and more important issue was the unrecognized network ethernet card. But I used an USB-ethernet adapter for the Qubes-OS installation. Then I updated to a latest kernel (5.6.16) which recognized my ethernet card. Then all rocks 
Verify the BIOS settings, I think it’s the main problem for you. See my HCL mailing-list post and also the question/answer from/to zhao in my HCL thread.
Are you using a very specific NUC10 or a very common like mine (NUC10i7FNK)? Check the differences between mine and yours.