How to Create `sys-usb` in Qubes OS Installed on an External USB SSD Without Breaking the System

Check if you have multiple USB controllers and they are available on the physical USB ports. If you have them then you can dedicate one of the USB controllers to dom0 and connect your USB disk to it.
Run this command in dom0 to see if there are multiple USB controllers available:

lspci | grep USB

Then check if there are different USB controllers connected to the different USB ports:

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