How can you resist system fingerprinting from malicious apps in qubes?

For example, if i create app qube for telegram/signal and launch it, it probably collects some telemetry data and if i create another app qube with telegram/signal the devs probably can probably connect two identities together with the telemetry. How can i resist this?

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You have limited choices, if you use standard qubes (with qubes integration).
Making your app qube standalone will help a bit, but xen will be detected in any case.
Using different net qubes, connected to different VPNs, will definitely help.

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Do not install known malicious applications to begin with.

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