Heads and Yubikey

Thanks to the forum members, I was able to install Heads. I also got a YubiKey, so I’m eager to start using Heads. However, I don’t know how to use the YubiKey with QubesOS. I’ve heard that most Heads users are also QubesOS users, so I thought this would be a good place to ask. Should I start by setting up the YubiKey in QubesOS?