I have ASRock b550 PRO4 motherboard, Ryzen 7 5700G desktop processor.
I saw Hardware compatibility list (HCL) and found that my motherboard is not listed but I found this regarding my processor.
The HCL entry that you linked does report that a machine with a similar processor did work as expected under R4.1-RC3, with the observation that it wouldn’t wake up from suspend. Am I reading this correctly?
If the “doesn’t wake up from suspend” is what worries you:
“suspend mode” not working in some way is a common situation on Qubes OS, and usually one of the things that only a few setups can do well
usually that means you’ll make sure that your machine doesn’t try to suspend (by disabling the option near the other “Power saving” settings) because having to force a shutdown is never nice
other than that (hard shutdowns, that you’ll avoid anyway), I don’t see how the hardware could get damaged. You should be safe to give a try to Qubes OS.
Does that make sense to you? Did I miss anything in that HCL report?