Thank you and I definitely will add a conclusion after having used it for a couple.
So far though, I would absolutely recommend it for Qubes as you are able to enjoy all of the benefits of the Framework with its modularity and expansion cards systems just like you would using any other distro, without any down sides whatsoever.
Only downside is the lack of keyboard on suspend but I’m trying to find a fix.
With my previous laptop, I would need to reboot any time I plugged something as simple as a usb to ethernet adapter to get the adapter recognised by Qubes. I was fully expecting with the Framework to have to reboot every time I switched input modules, but no not at all. Any new ones get detected automatically and I can start using them straightaway, even for things like the display output where I removed the DP expansion card and then plugged the HDMI one in and it detected it and extended the display to the output I connected, didn’t need to reboot or anything.
Also it is incredibly quiet, coming from a laptop which would spin up and sound like a jet engine on boot or under heavy load, at their peak so far the fans are barely discernible when there are no background sounds (FYI I do not have the dGPU module).
Additionally, I am running a test of the battery and it is over 2h and still going. For Qubes and given that this test is having the laptop at full brightness and running at around 30-50% CPU, I think that is quite good.
EDIT: Battery test is finished and added to the main post