To answer my own question I did some testing on this device. There are 6 controllers but it’s not as useful as that sounds.
1 - USB 2.0 Hub, not mapped to any port
2 - USB 2.0 Hub, not mapped to any port
3 - Top Left port
4 - Top Right Port
5 - Keyboard, Mediatek Wireless Device, Fingerprint Reader, Bottom 4 ports
6 - USB Camera
I don’t know what the first two controllers are for maybe the GPU module?
The fifth controller shares the keyboard and internet bluetooth so probably not acceptable for anyone that cares about isolating this. The camera is more isolated than the keyboard. You can maybe share some less important ports with the keyboard (chargers are maybe less likely to be a problem) but if you want ethernet that takes up 1 of the two other isolated ports you have because there is no dedicated ethernet pci port.
There are 3 controllers you can isolate ports with in total.
A framework 13 would at least be better because the keyboard and mouse is PS/2 Framework - Laptop 13 (Intel 13th Gen) - #6 by leee
But maybe a NovaCustom is better for isolation? NovaCustom NV41 Series - #19 by novacustom
It seems to have isolated keyboard/mouse, internet and audio with up to 3 isolated groups of USB ports?