Seems Qubes is to a standard distribution as OOP is to K&R C.
I hope not! shudder
What? … I like python … 
It’s really interesting topic!
Look at that: GitHub - mviereck/x11docker: Run GUI applications and desktops in docker and podman containers. Focus on security.
It runs separated x server with additional configuration so that you can control if you want clipboard, audio devices etc.
Imagine OS that:
- has Xen linux based dom0 (distro of your choice, e.g I like Void and Alpine)
- Uses DE of your choice
- Hypervisor is used by default to isolate network and usb devices (also uses similar, handy qubes-like tools to e.g. copy files)
- You have choice to isolate apps with docker/podman or true rock-solid qubes-like templateVM & appVM based.
I’d go for it
See also gvisor which looks promising for running containers securely
I liked the ASCII art of this.
I just found out about Plague OS, sounds a bit similar to Spectrum OS regarding being lighter and more hardware compatible than Qubes OS:
Hey!
RancherOS → https://rancher.com
is a fun project to test docker with qubes-os combo (Very nice!)
Step one:
Build ubuntu template
Step two:
Build latest rancher from git!
Step three:
edit iptables 
Let me know how it goes!
Cheers!
~X
There is also EasyOs, concept similar to Qubes but based on containers. Fun thing is that this is a new project from creator of Puppy so it not using docker but some new containers engine created specially for that project. It is also extremely light like puppy.
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