I tried first 4.1 beta on this laptop, but found out resume from suspend didn’t work, probably because of Xen 4.14 (https://github.com/QubesOS/qubes-issues/issues/6066).
Then tried 4.0. Installation was a pleasure. No tweaks, everything just works.
Qubes-HCL-Dell_Inc_-Latitude_E7450-20210817-151534.yml (877 Bytes)