after I tried to attach one of the USB controllers to another VM. So I removed one of the connected devices from the sys-usb and connected it to another VM. The VM could not start with this USB device. So I removed it in the VM and connected it again to the sys-usb. The VM can start again, but the sys-usb shows this error:
unable to reset PCI device XYZ: no FLR, PM reset or bus reset available
even after restart of the sys-usb and even after restart of the Laptop.