Can I install programs onto a Qubes Live USB?

New to Qubes and haven’t installed it yet, but I was wondering if I ran it from a USB drive, would I be able to install additional programs to it? Specifically I’m talking about Kleopatra. I’m used to PGP on Windows using Kleopatra, but have very limited Linux experience. Thanks for any help.

Qubes doesn’t have official Live ISO that you can flash on USB drive and boot from it to use the system.
You need to first install Qubes using Qubes installer ISO on one of your drives (you can install it on USB drive).